Drug Delivery: Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir (Adv. Sci. 2/2018)
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Multidrug Resistance in Cancer Circumvented Using a Cytosolic Drug Reservoir
It is discovered that sustained cytosolic drug release at a sufficient concentration is an effective mechanism to circumvent multidrug resistance and consequently enhance antitumor drug efficacy. It is showed that a simple way to enable this mechanism is to reach an intracellular kinetic balance of the drug movement between the drug released from the carrier into the cytosol and the one removed...
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